Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053888 | 0.89 | HTT (0.47) | HTTRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11052569 | 0.87 | ALDH1A1 (0.43) | HTTRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11053439 | 0.87 | HTT (0.42) | HTTRAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL11250897 | 0.86 | PKM (0.48) | HTTRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11053772 | 0.86 | HTT (0.38) | HTTRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11052091 | 0.86 | NPC1 (0.40) | HTTRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11052904 | 0.86 | HTT (0.47) | HTTPOLB | |
| SCHEMBL11049781 | 0.86 | KIF11 (0.46) | HTTSMN1; SMN2LMNA | |
| SCHEMBL11053656 | 0.86 | HTT (0.50) | HTTRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11055911 | 0.86 | HTT (0.41) | HTTRAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |