Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254196 | 0.84 | MAPT (0.55) | TBXA2RALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL11049566 | 0.82 | LCK (0.40) | ALDH1A1MAPK1MEN1KMT2AHTT | |
| SCHEMBL11048657 | 0.81 | HTT (0.47) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL11052848 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL11095796 | 0.81 | ALDH1A1 (0.41) | ALDH1A1GPR35MAPTMAPK1TDP1 | |
| SCHEMBL11049998 | 0.80 | MAPT (0.39) | ALDH1A1GPR35MAPTL3MBTL1MEN1 | |
| SCHEMBL11581851 | 0.80 | KCNMA1 (0.51) | TBXA2RALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL11051596 | 0.78 | KMT2A (0.55) | ALDH1A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL11052129 | 0.77 | POLB (0.46) | ALDH1A1MAPTMAPK1L3MBTL1MEN1 | |
| SCHEMBL11050873 | 0.77 | KMT2A (0.59) | ALDH1A1MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |