Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053990 | 0.90 | HCAR1 (0.48) | CHRNA7HCAR1EGFRFGFR1SRC | |
| SCHEMBL11052581 | 0.90 | HCAR1 (0.48) | CHRNA7HCAR1FGFR1KMT2A | |
| SCHEMBL11055617 | 0.84 | FGFR1 (0.39) | CHRNA7HCAR1EGFRFGFR1SRC | |
| SCHEMBL11059375 | 0.83 | HCAR1 (0.40) | CHRNA7HCAR1FGFR1KMT2A | |
| SCHEMBL11053190 | 0.83 | KDM4E (0.40) | CHRNA7HCAR1EGFRFGFR1SRC | |
| SCHEMBL11054450 | 0.83 | HCAR1 (0.40) | CHRNA7HCAR1 | |
| SCHEMBL11056242 | 0.83 | HCAR1 (0.40) | CHRNA7HCAR1KMT2A | |
| SCHEMBL11056476 | 0.83 | HCAR1 (0.40) | CHRNA7HCAR1FGFR1KMT2A | |
| SCHEMBL11059558 | 0.82 | FGFR1 (0.38) | CHRNA7HCAR1EGFRFGFR1SRC | |
| SCHEMBL11056344 | 0.81 | EGFR (0.37) | CHRNA7HCAR1EGFRFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |