Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053990 | 0.86 | HCAR1 (0.48) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL11057576 | 0.85 | ALDH1A1 (0.39) | HCAR1ANPEPP2RX3P2RX2DPP4 | |
| SCHEMBL11054591 | 0.82 | CHRNA7 (0.46) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL11055617 | 0.81 | FGFR1 (0.39) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL11053190 | 0.80 | KDM4E (0.40) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL11056344 | 0.78 | EGFR (0.37) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL11052581 | 0.74 | HCAR1 (0.48) | FGFR1HCAR1ANPEPDPP4ALDH1A1 | |
| SCHEMBL11053265 | 0.73 | HCAR1 (0.38) | HCAR1ANPEPNFKB1DPP4ALDH1A1 | |
| SCHEMBL11057586 | 0.70 | ELANE (0.36) | HCAR1ALDH1A1LMNA | |
| SCHEMBL11402688 | 0.69 | SRC (0.37) | FGFR1SRCEGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |