SCHEMBL11054922

SCHEMBL11054922

CC1(C(=O)Nc2ccc(OC(F)F)c(Cl)c2)CC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.57
MEN1 O00255 11/20 0.57
KMT2A Q03164 11/20 0.57
HTT P42858 8/20 0.57
LMNA P02545 8/20 0.57
ALDH1A1 P00352 6/20 0.57
TP53 P04637 1/20 0.57
HTR1E P28566 1/20 0.57
S1PR3 Q99500 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
SMN1; SMN2 Q16637 5/20 0.57
RAB9A P51151 4/20 0.57
NPSR1 Q6W5P4 2/20 0.57
GAA P10253 1/20 0.57
XBP1 P17861 1/20 0.57
CCR6 P51684 1/20 0.57
NPC1 O15118 3/20 0.55
NFKB1 P19838 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11049020 0.88 RORC (0.67) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11045834 0.86 KMT2A (0.46) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11049200 0.86 MEN1 (0.44) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11050893 0.85 SMN1; SMN2 (0.42) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11566094 0.84 SMN1; SMN2 (0.57) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11050028 0.82 BRAF (0.46) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11050975 0.82 PNLIP (0.49) MAPTMEN1KMT2ALMNAALDH1A1
SCHEMBL13811509 0.81 RORC (0.76) MAPTMEN1KMT2AHTTLMNA
SCHEMBL11562798 0.81 RORC (0.67) MAPTMEN1KMT2AHTTLMNA
SCHEMBL10777200 0.80 MAPT (0.64) MAPTMEN1KMT2AHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0052473-B1 N-SUBSTITUTED PHENYL-1-METHYLCYCLOPROPANECARBOXAMIDES, THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-08-22 EP disclosed
US-4447260-A N-Substituted phenyl-1-methylcyclopropanecarboxamides, and their herbicidal use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-05-08 US disclosed
EP-0052473-A2 N-Substituted phenyl-1-methylcyclopropanecarboxamides, their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1982-05-26 EP disclosed