SCHEMBL11056331

SCHEMBL11056331

CCc1cccc(CC)c1-n1cnc(N(C)C)nc1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 1/20 0.41
HCAR1 Q9BXC0 1/20 0.37
GRM1 Q13255 2/20 0.36
NPEPPS P55786 2/20 0.35
ALDH1A1 P00352 6/20 0.34
CYP1A2 P05177 6/20 0.34
CASP1 P29466 6/20 0.34
CASP7 P55210 6/20 0.34
HSD17B10 Q99714 5/20 0.34
HPGD P15428 3/20 0.34
MAPK1 P28482 3/20 0.34
HIF1A Q16665 3/20 0.34
CYP2C9 P11712 3/20 0.34
CYP2C19 P33261 3/20 0.34
CYP2D6 P10635 2/20 0.34
LMNA P02545 2/20 0.34
TP53 P04637 1/20 0.34
GLA P06280 1/20 0.34
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11060207 0.92 HCAR1 (0.38) MAT2AHCAR1GRM1NPEPPSALDH1A1
SCHEMBL11050218 0.90 HCAR1 (0.37) MAT2AHCAR1GRM1
SCHEMBL10541416 0.88 NPEPPS (0.36) MAT2AHCAR1GRM1NPEPPSALDH1A1
SCHEMBL11058424 0.88 HCAR1 (0.37) MAT2AHCAR1NPEPPSALDH1A1HPGD
SCHEMBL11351342 0.86 MAT2A (0.35) MAT2AHCAR1GRM1NPEPPSALDH1A1
SCHEMBL11351889 0.86 HCAR1 (0.34) MAT2AHCAR1GRM1NPEPPSALDH1A1
SCHEMBL11056509 0.85 GRM1 (0.34) MAT2AHCAR1GRM1NPEPPSALDH1A1
SCHEMBL11343649 0.84 HCAR1 (0.35) MAT2AHCAR1NPEPPSALDH1A1HPGD
SCHEMBL11347343 0.84 ANPEP (0.36) MAT2AHCAR1NPEPPSALDH1A1HPGD
SCHEMBL11056926 0.83 HCAR1 (0.46) MAT2AHCAR1ALDH1A1CYP1A2CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4298608-A LOCAL ANESTHETICS WILLIAM H. RORER, INC. (US) 1981-11-03 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4198408-A 1,4-DISUBSTITUTED-1,2-DIHYDRO-1,3,5-TRIHZIN-2-ONES WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed