SCHEMBL11058424

SCHEMBL11058424

CCc1cccc(CC)c1-n1cnc(N(CC)CC)nc1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 1/20 0.37
ALOX15 P16050 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPEPPS P55786 2/20 0.35
CRHR1 P34998 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ANPEP P15144 2/20 0.33
DPP4 P27487 2/20 0.33
MAT2A P31153 1/20 0.33
MAPT P10636 1/20 0.32
GABRA1 P14867 2/20 0.32
GABRB2 P47870 2/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
ELANE P08246 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11055471 0.92 HCAR1 (0.38) HCAR1ALOX15SMN1; SMN2NPEPPSCRHR1
SCHEMBL11060167 0.90 TDP1 (0.38) HCAR1ALOX15SMN1; SMN2ALDH1A1LMNA
SCHEMBL11347343 0.90 ANPEP (0.36) HCAR1NPEPPSCRHR1ALDH1A1LMNA
SCHEMBL11056331 0.88 MAT2A (0.41) HCAR1NPEPPSALDH1A1LMNAHPGD
SCHEMBL11359839 0.88 SLC29A1 (0.36) HCAR1NPEPPSALDH1A1LMNAHPGD
SCHEMBL11354038 0.86 CRHR1 (0.46) HCAR1SMN1; SMN2CRHR1ALDH1A1LMNA
SCHEMBL10541416 0.85 NPEPPS (0.36) HCAR1NPEPPSALDH1A1LMNAHPGD
SCHEMBL11343649 0.84 HCAR1 (0.35) HCAR1NPEPPSALDH1A1LMNAHPGD
SCHEMBL11351342 0.83 MAT2A (0.35) HCAR1NPEPPSALDH1A1LMNAHPGD
SCHEMBL11351889 0.83 HCAR1 (0.34) HCAR1NPEPPSALDH1A1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4298608-A LOCAL ANESTHETICS WILLIAM H. RORER, INC. (US) 1981-11-03 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4198408-A 1,4-DISUBSTITUTED-1,2-DIHYDRO-1,3,5-TRIHZIN-2-ONES WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed