Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11140619 | 0.84 | ALDH1A1 (0.42) | HTTL3MBTL1MAPTALDH1A1GAA | |
| SCHEMBL11278607 | 0.83 | HTT (0.39) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL11286642 | 0.83 | HTT (0.55) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL11059296 | 0.83 | RAPGEF4 (0.42) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11414461 | 0.82 | RAPGEF4 (0.41) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL10732669 | 0.82 | HTT (0.40) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL11428458 | 0.81 | HTT (0.40) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL11279723 | 0.81 | HTT (0.42) | HTTL3MBTL1TSHRMAPTALDH1A1 | |
| SCHEMBL11052671 | 0.80 | KDR (0.38) | HTTMAPTGAARAPGEF4LMNA | |
| SCHEMBL11274752 | 0.80 | TSHR (0.44) | HTTL3MBTL1TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |