SCHEMBL11057730

SCHEMBL11057730

CCNC(=S)N(C(=N)N)c1c(CC)cccc1CC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.35
ATM Q13315 1/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
CACNA1C Q13936 2/20 0.35
SCN5A Q14524 2/20 0.35
ALOX12 P18054 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GABRA1 P14867 2/20 0.34
GABRB2 P47870 2/20 0.34
TP53 P04637 2/20 0.32
CYP3A4 P08684 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GRIN3A Q8TCU5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11060096 0.87 ALDH1A1 (0.36) ALDH1A1MAPTGAACACNA1CSCN5A
SCHEMBL11051176 0.86 ALDH1A1 (0.32) ALDH1A1MAPTGAAALOX12SMN1; SMN2
Hydrochloric Acid SCHEMBL11141378 0.85 GRIN2D (0.35) ALDH1A1MAPTGAACACNA1CSCN5A
SCHEMBL11053011 0.85 POLB (0.37) ALDH1A1MAPTGAAALOX12SMN1; SMN2
SCHEMBL11054052 0.85 ALDH1A1 (0.50) ALDH1A1MAPTGAAALOX12SMN1; SMN2
SCHEMBL11060169 0.85 KMT2A (0.45) ALDH1A1MAPTGAAMEN1KMT2A
SCHEMBL11057749 0.84 ALDH1A1 (0.46) ALDH1A1MAPTGAASMN1; SMN2TP53
SCHEMBL11057149 0.84 CACNA1C (0.38) ALDH1A1CACNA1CSCN5ASMN1; SMN2GABRA1
SCHEMBL11059269 0.83 HTT (0.37) ALDH1A1MAPTGAAALOX12SMN1; SMN2
SCHEMBL11141768 0.83 GABRA1 (0.39) ALDH1A1MAPTGAACACNA1CSCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4418209-A ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS WILLIAM H. RORER, INC. (US) 1983-11-29 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed