Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057168 | 0.86 | ALOX5 (0.38) | KMT2AALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL11057730 | 0.85 | ALDH1A1 (0.35) | KMT2AALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL11052191 | 0.81 | ALOX5 (0.38) | KMT2AALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL11060096 | 0.81 | ALDH1A1 (0.36) | ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL11051176 | 0.81 | ALDH1A1 (0.32) | ALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL11141378 | 0.80 | GRIN2D (0.35) | ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL11054052 | 0.80 | ALDH1A1 (0.50) | KMT2AALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL11053011 | 0.80 | POLB (0.37) | KMT2AALDH1A1GAAL3MBTL1MEN1 | |
| SCHEMBL11057749 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL11057031 | 0.78 | HPGD (0.45) | KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4418209-A | ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS | WILLIAM H. RORER, INC. (US) | 1983-11-29 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |