Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058666 | 0.83 | ATR (0.37) | ATRL3MBTL1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11058186 | 0.80 | ALDH1A1 (0.33) | L3MBTL1HTTLMNASMN1; SMN2NPC1 | |
| SCHEMBL11057358 | 0.78 | MAP3K7 (0.36) | MAP3K7TAB1L3MBTL1HTTLMNA | |
| SCHEMBL11059945 | 0.78 | HTT (0.35) | L3MBTL1HTTKMT2ATDP1LMNA | |
| SCHEMBL11060673 | 0.77 | MAPK1 (0.35) | KMT2AIRAK4GSK3BALDH1A1 | |
| SCHEMBL11058659 | 0.74 | L3MBTL1 (0.41) | L3MBTL1HTTKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL11069400 | 0.73 | MAP3K7 (0.38) | MAP3K7TAB1L3MBTL1HTTKMT2A | |
| SCHEMBL11060944 | 0.70 | L3MBTL1 (0.35) | L3MBTL1CYP1A2CYP3A4MAPTGLA | |
| SCHEMBL16037977 | 0.70 | CDK1 (0.37) | ATRMAP3K7TAB1ALDH1A1 | |
| SCHEMBL11058625 | 0.68 | MAP3K7 (0.36) | ATRMAP3K7TAB1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |