Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | FES | P07332 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057358 | 0.93 | MAP3K7 (0.36) | PRKD3MAP4K4GSK3AGSK3BMAP4K2 | |
| SCHEMBL11058186 | 0.87 | ALDH1A1 (0.33) | GSK3AGSK3BALDH1A1 | |
| SCHEMBL11058666 | 0.80 | ATR (0.37) | KMT2A | |
| SCHEMBL11062437 | 0.79 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL11061052 | 0.79 | MAPK1 (0.41) | MAPK1CDC7PLK4CHEK1CHUK | |
| SCHEMBL11058623 | 0.77 | ATR (0.40) | GSK3BIRAK4KMT2AALDH1A1 | |
| SCHEMBL11055924 | 0.74 | MAPK1 (0.38) | MAPK1CDC7PLK4CHEK1CHUK | |
| SCHEMBL11060944 | 0.74 | L3MBTL1 (0.35) | — | |
| SCHEMBL11058678 | 0.74 | LMNA (0.39) | MAPK1CDC7PLK4CHEK1CHUK | |
| SCHEMBL11060716 | 0.73 | MEN1 (0.36) | CDK1CDK2XDHMEN1PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |