Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058190 | 0.85 | PARP10 (0.32) | GPBAR1CYP17A1 | |
| SCHEMBL11058625 | 0.84 | MAP3K7 (0.36) | GPBAR1ATR | |
| SCHEMBL11060675 | 0.81 | LMNA (0.33) | CDC7CDK2 | |
| SCHEMBL11058664 | 0.79 | — | — | |
| SCHEMBL10959345 | 0.77 | PLAU (0.41) | SIRT6NNMT | |
| SCHEMBL11058688 | 0.77 | POLB (0.35) | SIRT6NNMT | |
| SCHEMBL10956424 | 0.77 | HSD17B10 (0.33) | SIRT6NNMT | |
| SCHEMBL11060945 | 0.75 | RPS6KB1 (0.30) | — | |
| SCHEMBL6114094 | 0.75 | SLC13A5 (0.36) | GPBAR1CDC7CCNE1CDK2DBF4 | |
| SCHEMBL11061481 | 0.73 | PLAU (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |