Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058190 | 0.87 | PARP10 (0.32) | TSHRMKNK2 | |
| SCHEMBL11058669 | 0.81 | GPBAR1 (0.33) | CDC7CDK2 | |
| SCHEMBL11062439 | 0.81 | GABRP (0.35) | LMNAKMT2ACYP3A4MEN1MAPT | |
| SCHEMBL11061057 | 0.80 | MAP3K7 (0.37) | LMNAKMT2ACYP3A4CA12CA1 | |
| SCHEMBL11058625 | 0.78 | MAP3K7 (0.36) | MAP3K7TAB1GSK3B | |
| SCHEMBL11055926 | 0.76 | SMN1; SMN2 (0.35) | LMNAKMT2ACYP3A4CA12CA1 | |
| SCHEMBL11060945 | 0.76 | RPS6KB1 (0.30) | RPS6KB1 | |
| SCHEMBL11058684 | 0.75 | LMNA (0.43) | LMNAKMT2ACYP3A4MEN1NR1I2 | |
| SCHEMBL11060720 | 0.74 | CYP3A4 (0.36) | LMNAKMT2ACYP3A4MEN1NR1I2 | |
| SCHEMBL11058664 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |