Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061481 | 0.89 | PLAU (0.33) | PLAUACACBGABRG2GABRB3GABRA2 | |
| SCHEMBL11058688 | 0.85 | POLB (0.35) | POLBSIRT6NNMT | |
| SCHEMBL11060720 | 0.84 | CYP3A4 (0.36) | PLAUACACBGABRG2GABRB3GABRA2 | |
| SCHEMBL11059949 | 0.79 | ACACB (0.33) | ACACB | |
| SCHEMBL11061001 | 0.79 | MEN1 (0.35) | ACACB | |
| SCHEMBL11058669 | 0.77 | GPBAR1 (0.33) | SIRT6NNMT | |
| SCHEMBL11062631 | 0.76 | PLAU (0.37) | PLAUSIRT6NNMTPIK3CA | |
| SCHEMBL11062615 | 0.76 | POLB (0.33) | PLAUPOLB | |
| SCHEMBL6317506 | 0.74 | QPCT (0.35) | PLAUACACBQPCTQPCTLCYP1A2 | |
| SCHEMBL3192298 | 0.72 | NNMT (0.47) | PLAUACACBPOLBSIRT6NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039037-B1 | PYRIMIDYLTHIO-UREAS, MEDICINES CONTAINING THEM AND THEIR USE | Beiersdorf Aktiengesellschaft (DE) | 1985-01-16 | — | — | EP | claimed |
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |
| US-4323570-A | HYPOTENSIVE AGENTS AND TREATING GLAUCOMA | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-04-06 | — | — | US | disclosed |