Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057477 | 0.84 | MEN1 (0.48) | KMT2AMEN1PHGDHALDH1A1GAA | |
| SCHEMBL8935037 | 0.71 | MET (0.46) | KMT2AMEN1LMNAALDH1A1GAA | |
| SCHEMBL9229231 | 0.68 | KMT2A (0.33) | KMT2AALDH1A1 | |
| SCHEMBL95284 | 0.68 | PDK1 (0.68) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL11057194 | 0.68 | MAPK1 (0.53) | KMT2AMEN1PHGDHALDH1A1GAA | |
| SCHEMBL9062960 | 0.65 | MEN1 (0.59) | KMT2AMEN1PHGDHALDH1A1GAA | |
| SCHEMBL733777 | 0.65 | KMT2A (0.69) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL29740651 | 0.65 | KMT2A (0.69) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL24187914 | 0.64 | PDK1 (0.55) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL10041286 | 0.64 | PDK1 (0.71) | KMT2AMEN1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450108-A | ANTIDEPRESSANTS; NEUROLEPTIC AGENTS; PSYCHOLOGICAL DISORDERS | SANDOZ LTD. (CH) | 1984-05-22 | — | — | US | disclosed |
| EP-0031115-A1 | New pyrrolobenzotriazepines, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-07-01 | — | — | EP | disclosed |