Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068412 | 0.89 | MEN1 (0.54) | EGFRERBB2CA1CA2PRKCZ | |
| SCHEMBL11060811 | 0.84 | PRKCZ (0.56) | EGFRERBB2CA1CA2PRKCZ | |
| SCHEMBL11374953 | 0.84 | PRKCZ (0.53) | EGFRERBB2ERBB3KDRPTK2 | |
| SCHEMBL8637990 | 0.84 | PRKCZ (0.46) | EGFRERBB2ERBB3KDRPTK2 | |
| SCHEMBL10418603 | 0.84 | PRKCZ (0.46) | EGFRERBB2PRKCZMAPTMEN1 | |
| SCHEMBL25138590 | 0.80 | EGFR (0.78) | EGFRERBB2ERBB3KDRPTK2 | |
| SCHEMBL11096598 | 0.79 | EGFR (0.48) | EGFRERBB2ERBB3KDRPTK2 | |
| SCHEMBL908494 | 0.78 | CA1 (0.56) | EGFRERBB2CA1CA2PRKCZ | |
| SCHEMBL11064115 | 0.78 | MEN1 (0.58) | EGFRERBB2CA1CA2PRKCZ | |
| SCHEMBL11101684 | 0.78 | ALDH1A1 (0.65) | EGFRERBB2CA1CA2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447442-A | ANTIINFLAMMATORY, ANTIARTHRITIC, ANTIHISTAMINE, ANTIALLERGENS, ANALGESICS, BACTERICIDES, AND FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4432991-A | ANALGESICS, FUNGICIDE, BACTERICIDE, ANTIINFLAMMATORY, OR ANTIARTHRITIC AGENTS, ANTIALLERGENS, AND BRONCHODILATOR | AMERICAN CYANAMID COMPANY (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0070376-A1 | Heterocyclic substituted-amino-pyrazolines | AMERICAN CYANAMID COMPANY (US) | 1983-01-26 | — | — | EP | disclosed |
| US-4360680-A | ANALGESIC, ANTIINFLAMMATORY AGENT, FUNGICIDE AND BACTERICIDE | AMERICAN CYANAMID COMPANY (US) | 1982-11-23 | — | — | US | disclosed |
| US-4348527-A | ANALGESICS, BACTERICIDES, FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1982-09-07 | — | — | US | disclosed |