SCHEMBL11068412

SCHEMBL11068412

NC1=NN(c2ccccc2)C(c2ccccc2)C1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 12/20 0.54
KMT2A Q03164 12/20 0.54
ATM Q13315 8/20 0.54
HSP90AA1 P07900 2/20 0.54
MAPT P10636 6/20 0.53
KDM4E B2RXH2 6/20 0.53
L3MBTL1 Q9Y468 5/20 0.53
GLA P06280 5/20 0.53
MAPK1 P28482 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
POLB P06746 1/20 0.53
ALDH1A1 P00352 6/20 0.48
GAA P10253 5/20 0.48
HPGD P15428 2/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CFTR P13569 1/20 0.48
GOPC Q9HD26 1/20 0.48
PRKCZ Q05513 1/20 0.48
SMN1; SMN2 Q16637 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL908494 0.89 CA1 (0.56) MEN1KMT2AMAPTKDM4EL3MBTL1
SCHEMBL11060055 0.89 EGFR (0.53) MEN1KMT2AATMHSP90AA1MAPT
SCHEMBL11060811 0.89 PRKCZ (0.56) MEN1KMT2AATMCA1CA2
SCHEMBL11064115 0.89 MEN1 (0.58) MEN1KMT2AATMHSP90AA1MAPT
SCHEMBL10418596 0.86 MAPT (0.50) MEN1KMT2AATMHSP90AA1MAPT
SCHEMBL11102158 0.85 L3MBTL1 (0.69) MEN1KMT2AL3MBTL1GLAPOLB
SCHEMBL11101684 0.85 ALDH1A1 (0.65) MEN1KMT2AATMMAPTKDM4E
SCHEMBL10418603 0.85 PRKCZ (0.46) MEN1KMT2AATMHSP90AA1MAPT
SCHEMBL908137 0.85 PRKCZ (0.58) ATML3MBTL1CA1CA2PRKCZ
SCHEMBL8637990 0.85 PRKCZ (0.46) MEN1KMT2AATMHSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4447442-A ANTIINFLAMMATORY, ANTIARTHRITIC, ANTIHISTAMINE, ANTIALLERGENS, ANALGESICS, BACTERICIDES, AND FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1984-05-08 US disclosed
US-4432991-A ANALGESICS, FUNGICIDE, BACTERICIDE, ANTIINFLAMMATORY, OR ANTIARTHRITIC AGENTS, ANTIALLERGENS, AND BRONCHODILATOR AMERICAN CYANAMID COMPANY (US) 1984-02-21 US disclosed
EP-0070376-A1 Heterocyclic substituted-amino-pyrazolines AMERICAN CYANAMID COMPANY (US) 1983-01-26 EP disclosed
US-4360680-A ANALGESIC, ANTIINFLAMMATORY AGENT, FUNGICIDE AND BACTERICIDE AMERICAN CYANAMID COMPANY (US) 1982-11-23 US disclosed
US-4348527-A ANALGESICS, BACTERICIDES, FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1982-09-07 US disclosed
US-4268436-A OXIDATIVE DIAZOTIZATION WITH NITROSYLSULFURIC ACID, ALKALINE METAL NITRITES, OR ALKYL NITRITES AZIENDE COLORI NAZIONALI AFFINI ACNA S.P.A. (IT) 1981-05-19 US disclosed