Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072105 | 0.87 | SRD5A1 (0.35) | PTGS2ALOX5PTGS1NOTUMABCB11 | |
| SCHEMBL11060030 | 0.79 | LMNA (0.36) | — | |
| SCHEMBL11066774 | 0.72 | SRD5A1 (0.43) | SRD5A1SRD5A2 | |
| SCHEMBL11063950 | 0.71 | PTGS2 (0.33) | PTGS2ALOX5PTGS1ABCB11OXER1 | |
| SCHEMBL11062697 | 0.69 | LMNA (0.40) | — | |
| SCHEMBL11065609 | 0.65 | HRH1 (0.39) | ABCB11SRD5A1SRD5A2ABCB1 | |
| SCHEMBL11064537 | 0.64 | AKR1B1 (0.45) | PTGS2ABCB11SRD5A1SRD5A2 | |
| SCHEMBL8607662 | 0.61 | PTGS2 (0.57) | PTGDR2PTGS2PTGS1ABCB11SRD5A2 | |
| SCHEMBL11066911 | 0.61 | KDM1A (0.41) | ALOX5ABCB11SRD5A1SRD5A2ABCB1 | |
| SCHEMBL509958 | 0.59 | PTGDR2 (0.46) | PTGDR2PTGS2ABCB11ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |