Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063299 | 0.92 | ALDH1A1 (0.38) | LMNAL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11072105 | 0.89 | SRD5A1 (0.35) | L3MBTL1TDP1 | |
| SCHEMBL11065609 | 0.87 | HRH1 (0.39) | LMNAL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11062697 | 0.80 | LMNA (0.40) | LMNAL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11066911 | 0.80 | KDM1A (0.41) | LMNAL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11063136 | 0.79 | PTGDR2 (0.34) | — | |
| SCHEMBL11068179 | 0.77 | L3MBTL1 (0.45) | LMNAL3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL11073141 | 0.77 | AKR1B1 (0.42) | LMNAL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11066774 | 0.77 | SRD5A1 (0.43) | HTTHRH1SLC6A15 | |
| SCHEMBL11065512 | 0.76 | MAPK14 (0.40) | LMNAL3MBTL1ALDH1A1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |