Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.57 |
| ▸ | PPARG | P37231 | 7/20 | 0.57 |
| ▸ | PPARD | Q03181 | 7/20 | 0.57 |
| ▸ | PPARA | Q07869 | 7/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TLR2 | O60603 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | FABP4 | P15090 | 2/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL4451750 | 0.91 | TDP1 (0.56) | HDAC11TSHRALDH1A1TDP1ALOX15 | |
| Phthalic Anhydride SCHEMBL6437106 | 0.89 | ALOX15 (0.58) | HDAC11TSHRALDH1A1TDP1FABP4 | |
| Nonanoate SCHEMBL11749939 | 0.89 | CDC25A (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| Phthalic Anhydride SCHEMBL28312849 | 0.88 | ALOX15 (0.56) | HDAC11TSHRALDH1A1TDP1FABP4 | |
| Stearic Acid SCHEMBL3368084 | 0.87 | ASAH1 (0.45) | GPR84PPARGPPARDPPARAHDAC11 | |
| Phthalic Anhydride SCHEMBL9493894 | 0.85 | FFAR4 (0.58) | FFAR1FFAR4CDC25ACDC25BCDC25C | |
| Anthraquinone SCHEMBL6925768 | 0.84 | AKR1B1 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Phthalic Anhydride SCHEMBL23672547 | 0.84 | ALOX15 (0.67) | TSHRPTPN1ALDH1A1TDP1ALOX15 | |
| Phthalic Anhydride SCHEMBL28188306 | 0.82 | TDP1 (0.64) | HDAC11TSHRALDH1A1TDP1MEN1 | |
| Phthalic Acid SCHEMBL11322985 | 0.81 | ALDH1A1 (0.48) | HDAC11ALDH1A1TDP1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452936-A | Oligomerized acids as scorch inhibitors for carboxylated rubbers | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4005978-A | Candle wax composition | FELTON INTERNATIONAL, INC. (US) | 1977-02-01 | — | — | US | disclosed |