Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 6/20 | 0.44 |
| ▸ | CDC25B | P30305 | 6/20 | 0.44 |
| ▸ | CDC25C | P30307 | 5/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL11064641 | 0.87 | GPR84 (0.57) | ALDH1A1CDC25ACDC25BCDC25CGPR84 | |
| Palmitic Acid SCHEMBL28486893 | 0.82 | GPR84 (0.63) | ALDH1A1GPR84PPARGPPARDPPARA | |
| Myristic Acid SCHEMBL16667241 | 0.82 | GPR84 (0.63) | ALDH1A1GPR84PPARGPPARDPPARA | |
| Decanoic Acid SCHEMBL16667134 | 0.82 | GPR84 (0.63) | ALDH1A1GPR84PPARGPPARDPPARA | |
| Stearic Acid SCHEMBL8460661 | 0.82 | GPR84 (0.63) | ALDH1A1GPR84PPARGPPARDPPARA | |
| Sebacic Acid SCHEMBL4451750 | 0.79 | TDP1 (0.56) | ALDH1A1CDC25ACDC25BHDAC11TSHR | |
| Phthalic Anhydride SCHEMBL9493894 | 0.79 | FFAR4 (0.58) | CDC25ACDC25BCDC25CFFAR1FFAR4 | |
| Phthalic Anhydride SCHEMBL6437106 | 0.78 | ALOX15 (0.58) | ALDH1A1CDC25ACDC25BHDAC11TSHR | |
| Nonanoate SCHEMBL11749939 | 0.77 | CDC25A (0.46) | ALDH1A1CDC25ACDC25BCDC25CGPR84 | |
| Anthraquinone SCHEMBL6925768 | 0.76 | AKR1B1 (0.59) | ALDH1A1GPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089477-B1 | FLAME RETARDANT COMPOSITION COMPRISING DENDRITIC POLYMERS | BASF SE (DE) | 2012-06-06 | — | — | EP | disclosed |
| US-20100152376-A1 | FLAME RETARDANT COMPOSITION COMPRISING DENDRITIC POLYMERS | CIBA CORPORATION (US) | 2010-06-17 | — | — | US | disclosed |
| EP-2089477-A1 | FLAME RETARDANT COMPOSITION COMPRISING DENDRITIC POLYMERS | Ciba Holding Inc. (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008071575-A1 | FLAME RETARDANT COMPOSITION COMPRISING DENDRITIC POLYMERS | CIBA HOLDING INC. (CH) | 2008-06-19 | — | — | WO | disclosed |
| EP-1572703-B1 | PROCESS FOR THE PREPARATION OF A MELAMINE BASED FLAME RETARDANT AND POLYMER COMPOSITION | CIBA SC HOLDING AG (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1572703-A2 | PROCESS FOR THE PREPARATION OF A MELAMINE BASED FLAME RETARDANT AND POLYMER COMPOSITION | Ciba SC Holding AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004055029-A2 | PROCESS FOR THE PREPARATION OF A MELAMINE BASED FLAME RETARDANT AND POLYMER COMPOSITION | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2004-07-01 | — | — | WO | disclosed |