Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | DNM1L | O00429 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3015461 | 0.87 | TAAR1 (0.50) | AOC3HSD17B10HTR6ITGA2BTAAR1 | |
| SCHEMBL11071906 | 0.84 | AOC3 (0.49) | AOC3HSD17B10LMNAHTR6CHEK1 | |
| SCHEMBL11063733 | 0.82 | AOC3 (0.47) | AOC3HSD17B10HTR6ITGA2BTAAR1 | |
| SCHEMBL11265409 | 0.82 | HTR6 (0.52) | AOC3LMNAHTR6TAAR1 | |
| SCHEMBL11070162 | 0.81 | SCN4A (0.52) | AOC3ALDH1A1HSD17B10LMNAHTR6 | |
| SCHEMBL11265384 | 0.80 | AOC3 (0.45) | AOC3HSD17B10HTR6CHEK1ITGA2B | |
| SCHEMBL11064399 | 0.79 | AOC3 (0.51) | AOC3ALDH1A1HSD17B10LMNAHTR6 | |
| SCHEMBL11071226 | 0.79 | CETP (0.51) | AOC3HTR6SIGMAR1 | |
| SCHEMBL11064121 | 0.79 | AOC3 (0.51) | AOC3HTR6BAZ2A | |
| SCHEMBL11065972 | 0.76 | AOC3 (0.48) | AOC3ALDH1A1HTR6CHEK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312869-A | Monosubstituted piperazines | SCIENCE UNION ET CIE (FR) | 1982-01-26 | — | — | US | claimed |
| EP-0005091-B1 | MONOSUBSTITUTED PIPERAZINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1981-11-25 | — | — | EP | claimed |
| US-4479952-A | 1-(4-benzyl-2-thiazolyl) piperazine; antiinflammatory; immunomodulator | SCIENCE UNION ET CIE (FR) | 1984-10-30 | — | — | US | disclosed |
| US-4312869-A | Monosubstituted piperazines | SCIENCE UNION ET CIE (FR) | 1982-01-26 | — | — | US | disclosed |