Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 12/20 | 0.48 |
| ▸ | CNR1 | P21554 | 5/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063691 | 0.86 | CNR2 (0.52) | POLBCNR2CNR1MGAMGAA | |
| SCHEMBL11063216 | 0.82 | POLB (0.49) | POLBCNR2CNR1MGAMGAA | |
| SCHEMBL11068645 | 0.81 | POLB (0.54) | POLBCNR2CNR1MGAMGAA | |
| SCHEMBL10650270 | 0.80 | CNR2 (0.58) | POLBCNR2CNR1MGAMGAA | |
| Hydrochloric Acid SCHEMBL11062022 | 0.80 | GPR84 (0.56) | KDM4EALDH1A1 | |
| SCHEMBL24199375 | 0.77 | CNR2 (0.51) | POLBCNR2CDC25AICMTALDH1A1 | |
| SCHEMBL5469815 | 0.76 | CDC25A (0.55) | CNR2CNR1CDC25AICMTKDM4E | |
| SCHEMBL12558504 | 0.76 | CNR2 (0.58) | CNR2CNR1CDC25AICMTKDM4E | |
| SCHEMBL24199374 | 0.75 | CNR2 (0.52) | POLBCNR2CNR1ALDH1A1 | |
| SCHEMBL9029183 | 0.75 | LMNA (0.68) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447435-A | HYPOTENSIVE AGENTS | THE BOOTS COMPANY PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| US-4442109-A | 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for treating hypertension | THE BOOTS COMPANY LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |