Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 11/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11062222 | 0.89 | MEN1 (0.47) | POLBGAATP53CNR2ALDH1A1 | |
| SCHEMBL11063691 | 0.82 | CNR2 (0.52) | POLBGAACNR2MGAMSI | |
| SCHEMBL7321123 | 0.82 | GPR84 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL11065751 | 0.81 | POLB (0.51) | POLBGAACNR2MGAMSI | |
| SCHEMBL11063216 | 0.79 | POLB (0.49) | POLBGAACNR2MGAMSI | |
| SCHEMBL10650270 | 0.77 | CNR2 (0.58) | POLBGAACNR2MGAMSI | |
| SCHEMBL24199375 | 0.74 | CNR2 (0.51) | POLBCNR2CDC25AICMTALDH1A1 | |
| SCHEMBL5469815 | 0.72 | CDC25A (0.55) | CNR2CNR1CDC25AICMTKDM4E | |
| SCHEMBL12558504 | 0.72 | CNR2 (0.58) | CNR2CNR1CDC25AICMTKDM4E | |
| SCHEMBL9029183 | 0.71 | LMNA (0.68) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447435-A | HYPOTENSIVE AGENTS | THE BOOTS COMPANY PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| US-4442109-A | 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for treating hypertension | THE BOOTS COMPANY LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |