Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 12/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254758 | 0.87 | — | — | |
| SCHEMBL29493676 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL8844927 | 0.85 | CYP1A2 (0.50) | KMT2ATNFCYP1A2CYP2D6LTA4H | |
| SCHEMBL1507736 | 0.82 | CYP11B2 (0.56) | TBXAS1CYP11B1CYP11B2HRH3CYP1A2 | |
| SCHEMBL727185 | 0.80 | CYP1A2 (0.62) | TBXAS1CYP11B1CYP11B2HRH4HRH3 | |
| Pyrrole SCHEMBL28319269 | 0.79 | KMT2A (0.44) | KMT2ATNFHRH4HRH3CYP3A4 | |
| SCHEMBL625190 | 0.78 | CALM1 (0.57) | KMT2ACYP3A4CYP1A2LTA4H | |
| SCHEMBL29995759 | 0.78 | CYP11B1 (0.65) | TBXAS1CYP11B1CYP11B2HRH4HRH3 | |
| SCHEMBL177863 | 0.78 | CYP11B1 (0.65) | TBXAS1CYP11B1CYP11B2HRH4HRH3 | |
| SCHEMBL8763328 | 0.78 | KMT2A (0.42) | KMT2ATNFCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427682-A | ANTICOAGULANTS, ANTIINFLAMMATORY, HYPOTENSIVE, OR ANTIALLERGEN AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-01-24 | — | — | US | disclosed |
| US-4317828-A | ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-03-02 | — | — | US | disclosed |
| US-4271170-A | THROMBOXANE SYNTHETASE ENZYME INHIBITOR USEFUL IN TREATING INFLAMMATION, HYPERTENSION, THROMBUS, CEREBRAL APOPLEXY, ASTHMA, AND CARDIOVASCULAR DISORDERS | ONO PHARMACEUTICAL CO., LTD., (JP) | 1981-06-02 | — | — | US | disclosed |