Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.45 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 6/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601141 | 0.93 | PDE10A (0.55) | PDE10AMAPTTSHRRAB9ADRD3 | |
| SCHEMBL11282844 | 0.86 | PDE10A (0.53) | PDE10ADRD3DRD2HTR7GRM2 | |
| SCHEMBL11065995 | 0.86 | OPRM1 (0.56) | PDE10ADRD3HTR7HTR1AKDM4E | |
| Citric Acid SCHEMBL11067205 | 0.85 | PDE10A (0.44) | PDE10AMAPTTSHRRAB9ADRD3 | |
| SCHEMBL11062672 | 0.85 | MAPT (0.52) | PDE10ALMNASMN1; SMN2MAPTHTR7 | |
| SCHEMBL10601879 | 0.84 | DRD4 (0.54) | PDE10ALMNASMN1; SMN2MAPTDRD3 | |
| SCHEMBL11366877 | 0.82 | GRM2 (0.64) | PDE10ALMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL11062412 | 0.82 | KCNH2 (0.50) | PDE10ALMNASMN1; SMN2DRD3DRD2 | |
| SCHEMBL11063411 | 0.82 | MAPT (0.55) | PDE10ALMNAMAPTTSHRDRD3 | |
| SCHEMBL11072882 | 0.82 | DRD4 (0.56) | PDE10ADRD3DRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |