Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073385 | 0.88 | MAOA (0.45) | ALDH1A1MAOAMAOBGRM4SMN1; SMN2 | |
| SCHEMBL11071310 | 0.77 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2058933 | 0.71 | PKM (0.46) | PKM | |
| SCHEMBL14670515 | 0.69 | MAOA (0.51) | ALDH1A1MAOAMAOBPGK1LMNA | |
| SCHEMBL10831048 | 0.68 | PKM (0.47) | ALDH1A1SMN1; SMN2LMNATSHRPKM | |
| SCHEMBL11066633 | 0.67 | PKM (0.40) | ALDH1A1SMN1; SMN2LMNATSHRPKM | |
| SCHEMBL1244338 | 0.66 | MAOA (0.70) | ALDH1A1MAOAMAOBSMN1; SMN2HTT | |
| SCHEMBL14867199 | 0.66 | MAOA (0.50) | ALDH1A1MAOAMAOBSMN1; SMN2LMNA | |
| SCHEMBL4290043 | 0.64 | MAOA (0.58) | ALDH1A1MAOAMAOBSMN1; SMN2PGK1 | |
| SCHEMBL29846220 | 0.64 | MAOA (0.68) | ALDH1A1MAOAMAOBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | disclosed |