Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066638 | 0.88 | ALDH1A1 (0.44) | MAOAMAOBVNN1PGK1GRM4 | |
| SCHEMBL11068752 | 0.76 | PGK1 (0.40) | PGK1SMN1; SMN2LMNAGAAHTT | |
| SCHEMBL18292338 | 0.70 | MAOA (0.60) | MAOAMAOBVNN1PGK1MEN1 | |
| SCHEMBL11625224 | 0.68 | NPC1 (0.71) | MAOAMAOBVNN1MEN1KMT2A | |
| SCHEMBL1244338 | 0.67 | MAOA (0.70) | MAOAMAOBVNN1MEN1KMT2A | |
| SCHEMBL14278516 | 0.66 | MAOA (0.53) | MAOAMAOBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29846220 | 0.65 | MAOA (0.68) | MAOAMAOBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11195188 | 0.65 | NPC1 (0.66) | MAOAMAOBVNN1MEN1KMT2A | |
| SCHEMBL25920692 | 0.65 | — | — | |
| SCHEMBL595536 | 0.64 | SMN1; SMN2 (0.69) | MEN1KMT2ASMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | disclosed |