Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070274 | 0.80 | CHRM1 (0.55) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL11070150 | 0.78 | SLC18A3 (0.40) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11071606 | 0.77 | HTR6 (0.47) | HTR6POLBCHRM2CHRM4CHRM5 | |
| Iodide SCHEMBL11060156 | 0.76 | SLC18A3 (0.45) | HTR6POLBSLC18A3 | |
| SCHEMBL11061136 | 0.72 | KCNH2 (0.56) | DRD2DRD4 | |
| SCHEMBL11062798 | 0.70 | CHRM2 (0.60) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL11250180 | 0.69 | HTR6 (0.60) | HTR6POLB | |
| SCHEMBL11243620 | 0.69 | HTR6 (0.49) | HTR6POLBDRD4 | |
| Hydrochloric Acid SCHEMBL11238680 | 0.69 | HTR6 (0.46) | HTR6POLB | |
| SCHEMBL10568199 | 0.69 | SIGMAR1 (0.58) | CHRM2CHRM4CHRM5CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |