Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 known ✓ | P34969 | 6/20 | 0.48 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10599900 | 0.89 | HTR7 (0.49) | HTR7HTR1AHTR2ADRD3HTR2C | |
| Citric Acid SCHEMBL10604868 | 0.89 | HTR7 (0.47) | HTR7HTR1AHTR2ADRD3HTR2C | |
| Citric Acid SCHEMBL11067205 | 0.82 | PDE10A (0.44) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL11361973 | 0.81 | DRD2 (0.52) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL10602407 | 0.81 | HTR1A (0.44) | HTR7HTR1AHTR2ADRD3DRD2 | |
| Water SCHEMBL11067600 | 0.80 | DRD2 (0.51) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL8272366 | 0.78 | SIGMAR1 (0.53) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL11066133 | 0.78 | KCNH2 (0.49) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL10601551 | 0.74 | DRD4 (0.47) | HTR7HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL11063411 | 0.72 | MAPT (0.55) | HTR7HTR1ADRD3DRD2GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |