Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068819 | 0.81 | MAOA (0.44) | KDM4ESMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27200075 | 0.78 | KDM4E (0.44) | KDM4ETDP1ROCK2SMN1; SMN2LMNA | |
| SCHEMBL11071902 | 0.70 | MAOA (0.44) | KDM4ETDP1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7346618 | 0.70 | AURKA (0.36) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11073271 | 0.69 | MAOA (0.42) | KDM4ETDP1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL21358213 | 0.69 | KDM4E (0.42) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11090600 | 0.68 | MAOA (0.41) | KDM4ETDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1728678 | 0.67 | MAOA (0.47) | KDM4ETDP1ROCK2LMNAALDH1A1 | |
| SCHEMBL7345232 | 0.67 | KDM4E (0.46) | KDM4ETDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11074658 | 0.67 | AURKA (0.33) | KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |