Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346618 | 0.85 | AURKA (0.36) | AURKAPARP1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL7347592 | 0.76 | MAPK14 (0.39) | DRD1 | |
| SCHEMBL7341393 | 0.74 | KDM4E (0.39) | KDM4EDRD1 | |
| SCHEMBL7340073 | 0.72 | CSNK1A1 (0.39) | PARP1CSNK1A1TYRO3DYRK1BDDB1 | |
| SCHEMBL7348959 | 0.72 | CSNK1A1 (0.39) | PARP1CSNK1A1TYRO3DYRK1BDDB1 | |
| SCHEMBL7339006 | 0.68 | NOTUM (0.44) | AURKAPARP1KDM4E | |
| SCHEMBL7340109 | 0.68 | BCAT2 (0.40) | AURKAPARP1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL11092286 | 0.67 | AURKB (0.38) | AURKATDP1 | |
| SCHEMBL10966773 | 0.67 | FBP1 (0.34) | CSNK1A1DYRK1BKDM4E | |
| SCHEMBL11067992 | 0.67 | KDM4E (0.41) | KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |