Sugi Predict

Sugi Predict / Compounds / SCHEMBL27200075

SCHEMBL27200075

SCHEMBL27200075

O=C(O)c1cc2c([nH]c1=O)-c1ncccc1OC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ ALDH1A1 P00352 5/20 0.39
▸ HSD17B10 Q99714 4/20 0.39
▸ HPGD P15428 3/20 0.39
▸ HTT P42858 1/20 0.36
▸ ROCK2 O75116 2/20 0.35
▸ MAPT P10636 2/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ BLM P54132 1/20 0.34
▸ AGER Q15109 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ GAA P10253 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ NOTUM Q6P988 1/20 0.34
▸ RUNX1 Q01196 1/20 0.34
▸ GSK3A P49840 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21358213 0.88 KDM4E (0.42) KDM4ETDP1ALDH1A1HSD17B10HPGD
SCHEMBL11067992 0.78 KDM4E (0.41) KDM4ETDP1ALDH1A1HSD17B10HPGD
SCHEMBL27200082 0.76 KMT2A (0.36) TDP1ROCK2MAPTBLMGAA
SCHEMBL21358745 0.68 NOTUM (0.44) KDM4EALDH1A1HSD17B10HPGDHTT
SCHEMBL4507981 0.66 MAOB (0.43) KDM4ETDP1HSD17B10HPGDMAPT
SCHEMBL29606008 0.66 MAOB (0.43) KDM4ETDP1HSD17B10HPGDMAPT
SCHEMBL21356990 0.65 KDM4E (0.50) KDM4EALDH1A1HSD17B10HPGDGAA
SCHEMBL11068819 0.65 MAOA (0.44) KDM4EALDH1A1HSD17B10HPGDHTT
SCHEMBL270419 0.65 KDM4E (1.00) KDM4ETDP1ALDH1A1MAPTCYP3A4
SCHEMBL373592 0.65 DAO (0.64) KDM4ETDP1ALDH1A1MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025008288-A1 9-OXO-9,10-DIHYDRO-6H-PYRANO[3,2-B:4,5-B']DIPYRIDINE-8-CARBOXYLIC ACID DERIVATIVES CENTENARA LABS AG (CH) 2025-01-09 — — WO disclosed
WO-2025008288-A1 9-OXO-9,10-DIHYDRO-6H-PYRANO[3,2-B:4,5-B']DIPYRIDINE-8-CARBOXYLIC ACID DERIVATIVES CENTENARA LABS AG (CH) 2025-01-09 — — WO disclosed
WO-2025008288-A1 9-OXO-9,10-DIHYDRO-6H-PYRANO[3,2-B:4,5-B']DIPYRIDINE-8-CARBOXYLIC ACID DERIVATIVES CENTENARA LABS AG (CH) 2025-01-09 — — WO disclosed
US-11964986-B1 9-oxo-9,10-dihydro-6H-pyrano[3,2-b:4,5-b′]dipyridine-8-carboxylic acid derivatives REJUVERON TELOMERE THERAPEUTICS AG (CH) 2024-04-23 — — US disclosed
US-11964986-B1 9-oxo-9,10-dihydro-6H-pyrano[3,2-b:4,5-b′]dipyridine-8-carboxylic acid derivatives REJUVERON TELOMERE THERAPEUTICS AG (CH) 2024-04-23 — — US disclosed
US-11964986-B1 9-oxo-9,10-dihydro-6H-pyrano[3,2-b:4,5-b′]dipyridine-8-carboxylic acid derivatives REJUVERON TELOMERE THERAPEUTICS AG (CH) 2024-04-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11964986-B1 9-oxo-9,10-dihydro-6H-pyrano[3,2-b:4,5-b′]dipyridine-8-carboxylic acid derivatives DPP9, DPYD, QDPR KDM4E 1901/4885TDP1 1800/4885ALDH1A1 99/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.