Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078717 | 1.00 | ABCB11 (0.38) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11073121 | 0.94 | ABCB11 (0.40) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11075218 | 0.94 | SIGMAR1 (0.39) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11077158 | 0.94 | SIGMAR1 (0.39) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11077066 | 0.94 | CYP4F2 (0.38) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11068963 | 0.94 | SIGMAR1 (0.39) | ABCB11LMNAMAPTMAPK1CYP4F2 | |
| SCHEMBL11075681 | 0.93 | SIGMAR1 (0.41) | KDM5AKDM4CPHF8KDM2ANAAA | |
| SCHEMBL11077308 | 0.93 | SIGMAR1 (0.41) | KDM5AKDM4CPHF8KDM2ANAAA | |
| SCHEMBL11076593 | 0.93 | SIGMAR1 (0.41) | KDM5AKDM4CPHF8KDM2ANAAA | |
| SCHEMBL11071161 | 0.93 | SIGMAR1 (0.41) | KDM5AKDM4CPHF8KDM2ANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430339-A | PROPHYLAXIS, METABOLISM, GLUCOSE, FATS, HYPOGLYCEMIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-02-07 | — | — | US | disclosed |
| WO-1982000822-A1 | SUBSTITUTED OXIRANECARBOXYLIC ACIDS,THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | EISTETTER K | 1982-03-18 | — | — | WO | disclosed |