Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 6/20 | 0.42 |
| ▸ | DGKA | P23743 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071024 | 0.87 | FAAH (0.36) | TDP1FAAHL3MBTL1DHFRCYP3A4 | |
| SCHEMBL11067372 | 0.85 | TDP1 (0.41) | TDP1FAAHDGKAGAAMEN1 | |
| SCHEMBL28805202 | 0.69 | TDP1 (0.46) | TDP1FAAHDGKAL3MBTL1MEN1 | |
| Biphenyl SCHEMBL28557971 | 0.69 | DGKA (0.62) | DGKAALDH1A1CYP3A4 | |
| SCHEMBL10814092 | 0.69 | FAAH (0.52) | TDP1FAAHDGKAGAAL3MBTL1 | |
| SCHEMBL5352197 | 0.68 | DGKA (0.66) | FAAHDGKA | |
| SCHEMBL10766992 | 0.68 | DGKA (0.66) | TDP1DGKAMEN1KMT2A | |
| SCHEMBL5357954 | 0.68 | DGKA (0.66) | FAAHDGKA | |
| SCHEMBL8663024 | 0.68 | DGKA (0.66) | TDP1DGKAMEN1KMT2A | |
| SCHEMBL873938 | 0.68 | DGKA (0.66) | TDP1DGKAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |