Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069009 | 1.00 | KDM4E (0.39) | KDM4ESMN1; SMN2TSHRKAT2BGAA | |
| SCHEMBL13069905 | 0.71 | HRH3 (0.38) | TSHR | |
| SCHEMBL22781186 | 0.70 | KDM4E (0.39) | KDM4ESMN1; SMN2TSHRKAT2BGAA | |
| SCHEMBL2653195 | 0.69 | TSHR (0.35) | KDM4ESMN1; SMN2TSHRKAT2BGAA | |
| SCHEMBL14818161 | 0.69 | TSHR (0.39) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 | |
| SCHEMBL1312176 | 0.69 | CHRNB2 (0.39) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL30735282 | 0.68 | CHRNB2 (0.38) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 | |
| SCHEMBL29153128 | 0.67 | TSHR (0.37) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 | |
| SCHEMBL29153129 | 0.67 | TSHR (0.37) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 | |
| SCHEMBL7458942 | 0.67 | ALDH1A1 (0.37) | KDM4ESMN1; SMN2TSHRGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443467-A | N-DIAMINOMETHYLENE-(2,5-DIHYDRO-1H-PYRROL-1-YL)ACETAMIDES | JOHN WYETH & BROTHER, LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| EP-0040947-A1 | Use of guanidines for manufacturing antidiarrhoeal medicaments and antidiarrhoeal compositions containing these guanidines | JOHN WYETH & BROTHER LIMITED (GB) | 1981-12-02 | — | — | EP | disclosed |