Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 3/20 | 0.52 |
| ▸ | CES1 | P23141 | 3/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA6 | P23280 | 3/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL2679685 | 1.00 | NAPRT (0.61) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL27577743 | 0.90 | TRPA1 (0.65) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL6463794 | 0.89 | TSHR (0.64) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28621884 | 0.88 | ALDH1A1 (0.55) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL7669891 | 0.84 | TSHR (0.78) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL2019528 | 0.84 | TSHR (0.78) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28096536 | 0.83 | NAPRT (0.61) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL3827683 | 0.82 | TSHR (0.67) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28232473 | 0.82 | TRPA1 (0.65) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL23212125 | 0.80 | NAPRT (0.64) | NAPRTTSHRDAOCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478876-A | BLEND OF ACRYLATE MONOMER, COLLOIDAL SILICA, ACRYLOXY FUNCTIONAL SILANE, AND PHOTOINITIATORS | GENERAL ELECTRIC COMPANY (US) | 1984-10-23 | — | — | US | claimed |