Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 3/20 | 0.52 |
| ▸ | CES1 | P23141 | 3/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA6 | P23280 | 3/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL11069756 | 1.00 | NAPRT (0.61) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL27577743 | 0.90 | TRPA1 (0.65) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL6463794 | 0.89 | TSHR (0.64) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28621884 | 0.88 | ALDH1A1 (0.55) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL7669891 | 0.84 | TSHR (0.78) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL2019528 | 0.84 | TSHR (0.78) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28096536 | 0.83 | NAPRT (0.61) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL3827683 | 0.82 | TSHR (0.67) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL28232473 | 0.82 | TRPA1 (0.65) | NAPRTTSHRDAOCES2CES1 | |
| Benzoic Acid SCHEMBL23212125 | 0.80 | NAPRT (0.64) | NAPRTTSHRDAOCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478876-A | BLEND OF ACRYLATE MONOMER, COLLOIDAL SILICA, ACRYLOXY FUNCTIONAL SILANE, AND PHOTOINITIATORS | GENERAL ELECTRIC COMPANY (US) | 1984-10-23 | — | — | US | claimed |
| CN-102421856-B | UV-curable protective layer for thermoplastic substrates | BAYER MATERIALSCIENCE AG | 2014-08-27 | — | — | CN | disclosed |
| US-8753739-B2 | UV-curing protective layer for thermoplastic substrates | BAYER MATERIALSCIENCE AG (DE) | 2014-06-17 | — | — | US | disclosed |
| CN-101466805-B | UV-curable protective layer for thermoplastic substrates | BAYER MATERIALSCIENCE AG | 2013-08-07 | — | — | CN | disclosed |
| US-20120114933-A1 | UV-CURING PROTECTIVE LAYER FOR THERMOPLASTIC SUBSTRATES | BAYER MATERIALSCIENCE AG (DE) | 2012-05-10 | — | — | US | disclosed |
| CN-102421856-A | UV-curable protective layer for thermoplastic substrates | BAYER MATERIALSCIENCE AG | 2012-04-18 | — | — | CN | disclosed |
| EP-1500098-B1 | METHOD FOR MAKING LIMITED PLAY DATA STORAGE MEDIA | GEN ELECTRIC (US) | 2009-06-24 | — | — | EP | disclosed |
| CN-101466805-A | UV-curable protective layer for thermoplastic substrates | BAYER MATERIALSCIENCE AG (DE) | 2009-06-24 | — | — | CN | disclosed |
| EP-1371059-B1 | LIMITED PLAY DATA STORAGE MEDIA AND METHOD FOR LIMITING ACCESS TO DATA THEREON | GEN ELECTRIC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1969595-A2 | STORAGE MEDIA AND ASSOCIATED METHOD | GENERAL ELECTRIC COMPANY (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-0565310-B1 | Method of making a UV-curable hardcoat compositions | GEN ELECTRIC (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5468789-A | Devolatilization under inert atmosphere mixture containing specified anaerobic gelation inhibitors; weatherproofing thermoplastic substrates | GENERAL ELECTRIC COMPANY (US) | 1995-11-21 | — | — | US | disclosed |
| US-5466491-A | Polymer substrate with curable coating and gelation inhibitor sensitive to radiation | GENERAL ELECTRIC COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5318850-A | A mixture consisting of silica, hydrolysis product of an alkoxysilyl acrylate, acrylate monomer having hexanediol diacrylate, isobornyl acrylate or cyclohexyl acrylate and a photoinitiators | GENERAL ELECTRIC COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0576247-A2 | Radiation curable hardcoat compositions | GENERAL ELECTRIC COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0565310-A1 | Method of making a UV-curable hardcoat compositions | GENERAL ELECTRIC COMPANY (US) | 1993-10-13 | — | — | EP | disclosed |
| US-5242719-A | Reaction of multifunctional acrylate and silyl functional acrylate and silicon dioxide | GENERAL ELECTRIC COMPANY (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0544465-A1 | UV curable abrasion-resistant coatings | GENERAL ELECTRIC COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4491508-A | Method of preparing curable coating composition from alcohol, colloidal silica, silylacrylate and multiacrylate monomer | GENERAL ELECTRIC COMPANY (US) | 1985-01-01 | — | — | US | disclosed |
| US-4455205-A | ULTRAVIOLET RADIATION, WEAR RESISTANCE COATINGS | GENERAL ELECTRIC COMPANY (US) | 1984-06-19 | — | — | US | disclosed |