Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11073940 | 0.84 | LMNA (0.47) | KDM4EMAPTALDH1A1HSD17B10HTT | |
| SCHEMBL11066127 | 0.76 | SMN1; SMN2 (0.45) | KDM4EGAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL2843820 | 0.76 | ALDH1A1 (0.59) | KDM4EGAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL10272389 | 0.71 | GRM5 (0.45) | KDM4EGAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL1713222 | 0.70 | TSHR (0.57) | KDM4EGAAMAPTALDH1A1HTT | |
| SCHEMBL915018 | 0.70 | GAA (0.45) | KDM4EGAAMAPTALDH1A1HTT | |
| SCHEMBL2078431 | 0.69 | SMYD3 (0.47) | KDM4EGAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL1670363 | 0.69 | RAD52 (0.56) | KDM4EGAAMAPTALDH1A1HSD17B10 | |
| SCHEMBL5880357 | 0.69 | KDM4E (0.48) | KDM4EMAPTALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL158497 | 0.69 | TSHR (0.55) | KDM4EGAAMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486433-A | SLOWING HEART RATE | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-04 | — | — | US | disclosed |
| US-4409220-A | Fused-ring amino-pyrazines as bradycardiac agents | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-10-11 | — | — | US | disclosed |