Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260642 | 0.84 | PTGER1 (0.62) | PTGER1PTGER3PTGER2XDHTDP1 | |
| SCHEMBL2477166 | 0.80 | PTGER1 (0.47) | PTGER1PTGER3PTGER2XDHTDP1 | |
| SCHEMBL10714012 | 0.78 | BACE1 (0.53) | BACE1TSHRTP53CA12CA1 | |
| SCHEMBL24161843 | 0.77 | ALDH1A1 (0.50) | MEN1LMNAKMT2ABACE1TSHR | |
| SCHEMBL8926730 | 0.77 | ESR2 (0.53) | PTGER1PTGER3PTGER2XDHTDP1 | |
| SCHEMBL1631167 | 0.77 | PTGS2 (0.54) | PTGER1PTGER3PTGER2XDHTDP1 | |
| SCHEMBL3161240 | 0.77 | XDH (0.41) | XDHTDP1MEN1LMNATHRB | |
| SCHEMBL11037379 | 0.76 | ERN1 (0.57) | PTGER1PTGER3PTGER2ERN1PTGS1 | |
| SCHEMBL19153573 | 0.76 | AR (0.47) | PTGER1PTGER3PTGER2ERN1PDE3B | |
| SCHEMBL15331304 | 0.76 | EIF4E (0.55) | PTGER1PTGER3PTGER2XDHTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471117-A | ANTIDEPRESSANTS AND ANTI-PARKINSON AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-09-11 | — | — | US | disclosed |
| EP-0021807-B1 | 3,4-DIHYDRO-2H-PYRIMIDO (2,1-B) BENZOTHIAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-03-09 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |
| EP-0021806-A1 | 2,3-Dihydro-imidazo (2,1-b) benzothiazole derivatives and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |
| EP-0021807-A1 | 3,4-Dihydro-2H-pyrimido (2,1-b) benzothiazoles and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |