Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6306521 | 0.84 | TSHR (0.44) | ALDH1A1SMN1; SMN2RAB9AGAATSHR | |
| SCHEMBL11072823 | 0.80 | TSHR (0.55) | ALDH1A1SMN1; SMN2RAB9AGAATSHR | |
| SCHEMBL4516367 | 0.77 | TSHR (0.49) | ALDH1A1SMN1; SMN2GAATSHRPOLB | |
| SCHEMBL568818 | 0.77 | TSHR (0.47) | ALDH1A1SMN1; SMN2RAB9AGAATSHR | |
| SCHEMBL11074610 | 0.76 | NOTUM (0.43) | ALDH1A1SMN1; SMN2MAPTL3MBTL1TDP1 | |
| SCHEMBL2745877 | 0.75 | — | — | |
| SCHEMBL3635136 | 0.75 | TSHR (0.63) | ALDH1A1SMN1; SMN2GAATSHRPOLB | |
| SCHEMBL2223429 | 0.75 | TSHR (0.63) | ALDH1A1SMN1; SMN2GAATSHRPOLB | |
| SCHEMBL11181094 | 0.73 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2RAB9AGAATSHR | |
| SCHEMBL675456 | 0.73 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486433-A | SLOWING HEART RATE | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-04 | — | — | US | disclosed |
| US-4409220-A | Fused-ring amino-pyrazines as bradycardiac agents | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-10-11 | — | — | US | disclosed |