Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.42 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071332 | 0.83 | LMNA (0.47) | MAPK1MEN1KMT2ACNR1CNR2 | |
| SCHEMBL11081687 | 0.80 | CNR1 (0.59) | ALDH1A1HSD17B10HPGDALOX15MAPK1 | |
| SCHEMBL11071848 | 0.79 | CNR1 (0.57) | ALDH1A1HPGDMEN1KMT2ACNR1 | |
| SCHEMBL11070514 | 0.78 | CNR1 (0.57) | ALDH1A1ALOX15MAPK1MEN1KMT2A | |
| SCHEMBL10973972 | 0.78 | CNR1 (0.57) | ALDH1A1HPGDKMT2ACNR1CNR2 | |
| SCHEMBL11076340 | 0.78 | CNR1 (0.45) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL11074709 | 0.77 | CNR1 (0.56) | ALDH1A1HSD17B10HPGDALOX15CNR1 | |
| SCHEMBL11079598 | 0.77 | CNR1 (0.56) | ALDH1A1CNR1CNR2SMN1; SMN2TSHR | |
| SCHEMBL10974998 | 0.77 | CNR1 (0.49) | ALDH1A1ALOX15MAPK1MEN1KMT2A | |
| SCHEMBL11072620 | 0.77 | CNR1 (0.53) | ALDH1A1HPGDMEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451467-A | HYPOTENSIVE AGENTS | Ishikawa, Masayuki (JP) | 1984-05-29 | — | — | US | disclosed |
| EP-0056637-A1 | 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds | Ishikawa, Masayuki (JP) | 1982-07-28 | — | — | EP | disclosed |
| US-4276295-A | VASODILATORS, HYPOTENSIVE, ANTIATHEROSCLEROTIC | Ishikawa, Masayuki (JP) | 1981-06-30 | — | — | US | disclosed |