SCHEMBL11073623

SCHEMBL11073623

F/C(Cl)=C\c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 3/20 0.48
ALDH1A1 P00352 3/20 0.43
TSHR P16473 2/20 0.43
AKR1C3 P42330 1/20 0.43
MAPT P10636 2/20 0.42
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
AKR1C1 Q04828 1/20 0.41
ESR1 P03372 1/20 0.41
KDM1A O60341 1/20 0.41
POLB P06746 1/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9245051 1.00 FBP1 (0.48) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL17836924 1.00 FBP1 (0.48) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL7514100 0.78 MAPT (0.46) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL19712515 0.78 ALDH1A1 (0.46) FBP1ALDH1A1TSHRAKR1C3AKR1C1
SCHEMBL15709853 0.78 ALDH1A1 (0.46) FBP1ALDH1A1TSHRAKR1C3AKR1C1
SCHEMBL466536 0.78 ALDH1A1 (0.46) FBP1ALDH1A1TSHRAKR1C3AKR1C1
SCHEMBL40189 0.78 FBP1 (0.52) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL6438925 0.78 FBP1 (0.52) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL7184139 0.78 FBP1 (0.52) FBP1ALDH1A1TSHRAKR1C3MAPT
SCHEMBL19712514 0.78 ALDH1A1 (0.46) FBP1ALDH1A1TSHRAKR1C3AKR1C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421702-B2 Method for producing fluorine-containing olefin AGC Inc. (JP) 2019-09-24 US disclosed
US-20180086684-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN ASAHI GLASS COMPANY, LIMITED (JP) 2018-03-29 US disclosed
US-9796647-B2 Method for producing fluorine-containing olefin ASAHI GLASS COMPANY, LIMITED (JP) 2017-10-24 US disclosed
US-20170101360-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN ASAHI GLASS COMPANY, LIMITED (JP) 2017-04-13 US disclosed
US-9598335-B2 Method for producing fluorine-containing olefin ASAHI GLASS COMPANY, LIMITED (JP) 2017-03-21 US disclosed
EP-3042889-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN Asahi Glass Company, Limited (JP) 2016-07-13 EP disclosed
US-20160176791-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN ASAHI GLASS COMPANY, LIMITED (JP) 2016-06-23 US disclosed
US-4424166-A Preparation of 1,1-dihalogeno-alkenes BAYER AKTIENGESELLSCHAFT (DE) 1984-01-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180086684-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN FOS, CYP2F1, CYP4F11 FBP1 227/4885ALDH1A1 607/4885TSHR 1612/4885
US-10421702-B2 Method for producing fluorine-containing olefin FOS, CYP2F1, CYP4F11 FBP1 227/4885ALDH1A1 607/4885TSHR 1612/4885
US-20170101360-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN FOS, CYP2F1, CYP4F11 FBP1 227/4885ALDH1A1 607/4885TSHR 1612/4885
US-20160176791-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN FOS, CYP2F1, CYP4F11 FBP1 227/4885ALDH1A1 607/4885TSHR 1612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.