Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | YES1 | P07947 | 3/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11695830 | 0.76 | ATM (0.63) | MAPK1AURKBYES1NTRK1ABL1 | |
| SCHEMBL31241015 | 0.76 | RAB9A (0.58) | MAPK1KDM4ENPC1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL11700933 | 0.75 | ATM (0.62) | MAPK1AURKBYES1NTRK1ABL1 | |
| SCHEMBL11069813 | 0.75 | ADORA2B (0.44) | MAPK1AURKBYES1NTRK1ABL1 | |
| SCHEMBL25495309 | 0.74 | DEGS1 (0.49) | MAPK1AURKBYES1NTRK1ABL1 | |
| SCHEMBL22648398 | 0.73 | MDM2 (0.67) | KDM4ENPC1ALDH1A1TP53GAA | |
| SCHEMBL18979433 | 0.72 | DEGS1 (0.53) | WNT3AKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL31672286 | 0.72 | DEGS1 (0.53) | WNT3AKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL12376730 | 0.72 | RAB9A (0.60) | AURKBKDM4ENPC1GAARAB9A | |
| SCHEMBL11697032 | 0.72 | ATM (0.58) | MAPK1AURKBYES1NTRK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448780-A | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-05-15 | — | — | US | disclosed |