SCHEMBL11073705

SCHEMBL11073705

CNC1(c2cccc(OC)c2)CCC(=O)CC1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
SIGMAR1 Q99720 2/20 0.44
OPRM1 P35372 2/20 0.44
OPRL1 P41146 2/20 0.44
KDM1A O60341 1/20 0.43
ALOX5 P09917 1/20 0.42
SLC6A4 P31645 3/20 0.41
SLC6A2 P23975 2/20 0.41
SLC22A1 O15245 1/20 0.41
HSD11B1 P28845 1/20 0.41
KMT2A Q03164 2/20 0.41
KCNA3 P22001 1/20 0.41
MEN1 O00255 1/20 0.40
ADAM17 P78536 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene SCHEMBL11079878 0.97 HDAC3 (0.43) HDAC3HDAC1HDAC2HDAC6SIGMAR1
SCHEMBL14017660 0.88 OPRM1 (0.54) HDAC3HDAC1HDAC2HDAC6OPRM1
SCHEMBL17790240 0.83 SLC6A4 (0.50) HDAC3HDAC1HDAC2HDAC6OPRM1
SCHEMBL11091173 0.81 OPRM1 (0.55) HDAC3HDAC1HDAC2HDAC6OPRM1
SCHEMBL11073748 0.80 ALOX5 (0.55) ALOX5ADAM17
SCHEMBL613629 0.79 ALDH1A1 (0.56) SIGMAR1OPRM1OPRL1KDM1AALOX5
SCHEMBL11092837 0.79 SLC6A4 (0.46) HDAC3HDAC1HDAC2HDAC6OPRM1
SCHEMBL613824 0.79 KDM1A (0.49) SIGMAR1KDM1AALOX5SLC6A4HSD11B1
Ethylene SCHEMBL11074499 0.79 ALOX5 (0.53) ALOX5ADAM17
Ethylene SCHEMBL11093865 0.78 HDAC4 (0.41) HDAC3HDAC1HDAC2HDAC6OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4065573-A ANALGESICS THE UPJOHN COMPANY (US) 1977-12-27 US claimed
US-4460604-A ANALGESICS, NARCOTIC ANTAGONIST THE UPJOHN COMPANY (US) 1984-07-17 US disclosed
US-4447454-A Analgetic compounds, compositions and process of treatment THE UPJOHN COMPANY (US) 1984-05-08 US disclosed
US-4180584-A ANALGESIC; NARCOTIC ANTAGONIST THE UPJOHN COMPANY (US) 1979-12-25 US disclosed
US-4113866-A ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT THE UPJOHN COMPANY (US) 1978-09-12 US disclosed
US-4065573-A ANALGESICS THE UPJOHN COMPANY (US) 1977-12-27 US disclosed