Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.55 |
| ▸ | F10 | P00742 | 5/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745220 | 0.86 | OPRM1 (0.69) | OPRM1OPRL1F10SLC6A4SLC6A3 | |
| SCHEMBL16461202 | 0.82 | OPRM1 (0.60) | OPRM1OPRL1SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL11073705 | 0.81 | HDAC3 (0.44) | OPRM1OPRL1KCNA3SLC6A4ALDH1A1 | |
| SCHEMBL11097091 | 0.81 | SLC6A4 (0.39) | OPRM1OPRL1F10SLC6A4SLC6A3 | |
| SCHEMBL8284915 | 0.81 | OPRM1 (0.59) | OPRM1OPRL1SLC6A4SLC6A3GRIN1 | |
| SCHEMBL11092230 | 0.80 | PDE4B (0.47) | SLC6A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11067006 | 0.79 | SLC6A4 (0.44) | OPRM1OPRL1SLC6A4SLC6A3HSD11B1 | |
| SCHEMBL11092884 | 0.79 | SLC6A4 (0.40) | OPRM1OPRL1F10SLC6A4SLC6A3 | |
| SCHEMBL11091107 | 0.79 | HSD11B1 (0.41) | OPRM1OPRL1F10SLC6A4SLC6A3 | |
| Ethylene SCHEMBL11079878 | 0.79 | HDAC3 (0.43) | OPRM1OPRL1KCNA3SLC6A4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | claimed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |