Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL11098599 | 0.97 | OPRM1 (0.42) | OPRM1OPRL1OPRK1OPRD1SIGMAR1 | |
| Ethylene SCHEMBL10832290 | 0.97 | OPRD1 (0.41) | OPRM1OPRL1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL11557913 | 0.87 | OPRM1 (0.43) | OPRM1OPRK1OPRD1SIGMAR1MEN1 | |
| SCHEMBL11092002 | 0.86 | OPRM1 (0.44) | OPRM1OPRK1OPRD1SIGMAR1MEN1 | |
| SCHEMBL11088337 | 0.85 | SIGMAR1 (0.41) | OPRM1OPRK1OPRD1SIGMAR1MEN1 | |
| Ethylene SCHEMBL11099465 | 0.84 | OPRM1 (0.42) | OPRM1OPRK1OPRD1SIGMAR1MEN1 | |
| SCHEMBL11094528 | 0.84 | OPRM1 (0.42) | OPRM1OPRL1OPRK1OPRD1MEN1 | |
| SCHEMBL11093463 | 0.84 | DRD3 (0.39) | OPRM1OPRD1SIGMAR1 | |
| SCHEMBL11559890 | 0.83 | OPRM1 (0.38) | OPRM1OPRL1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL11090455 | 0.83 | OPRM1 (0.38) | OPRM1OPRL1OPRK1OPRD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | claimed |
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |