Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.65 |
| ▸ | ADRB2 known ✓ | P07550 | 11/20 | 0.50 |
| ▸ | ADRB1 known ✓ | P08588 | 9/20 | 0.50 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.50 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.50 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.50 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11075555 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| SCHEMBL11076646 | 0.95 | ALDH1A1 (0.71) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| Fumaric Acid SCHEMBL11079537 | 0.88 | MEN1 (0.61) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| Fumaric Acid SCHEMBL11079526 | 0.88 | MEN1 (0.61) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| SCHEMBL7267140 | 0.85 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| SCHEMBL11075561 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| SCHEMBL11072987 | 0.83 | MEN1 (0.67) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| Phenylacetic Acid SCHEMBL10573650 | 0.82 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| Diphenylacetic Acid SCHEMBL9799481 | 0.79 | MEN1 (0.65) | ALDH1A1MEN1KMT2AADRB2ADRB3 | |
| Hydrochloric Acid SCHEMBL11025071 | 0.79 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450115-A | ADRENERGIC BLOCKING AGENTS; HYPOTENSIVE AND CARDIOTONIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-05-22 | — | — | US | disclosed |
| US-4381398-A | Amino-alcohol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-04-26 | — | — | US | disclosed |