Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248429 | 0.80 | MEN1 (0.50) | KMT2AMAPTKDM4ELMNAHTT | |
| SCHEMBL11128885 | 0.72 | SLC40A1 (0.31) | KMT2AMAPTKDM4EPOLB | |
| SCHEMBL17814239 | 0.68 | ATM (0.47) | ATMKMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL11237723 | 0.65 | MAPT (0.43) | KMT2AMAPTKDM4EPOLBMAPK1 | |
| SCHEMBL31536367 | 0.65 | KMT2A (0.36) | KMT2AMAPTKDM4EPOLBLMNA | |
| SCHEMBL17169742 | 0.64 | KMT2A (0.39) | KMT2AKDM4ELMNAMEN1CYP2C9 | |
| SCHEMBL26048255 | 0.64 | KMT2A (0.39) | KMT2AKDM4ELMNAMEN1CYP2C9 | |
| SCHEMBL5523699 | 0.64 | KMT2A (0.39) | KMT2AKDM4EMAPK1LMNAMEN1 | |
| SCHEMBL31276971 | 0.64 | ATM (0.53) | ATMKMT2AMAPTKDM4EPOLB | |
| SCHEMBL7685977 | 0.64 | KMT2A (0.35) | KMT2AKDM4ELMNAMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001290-B1 | SUBSTITUTED 2,3-DIHYDROBENZ-(D)-ISOTHIAZOLE-1,1-DIOXIDES AND 2,3-DIHYDRONAPHTHO-(1,8-DE)-1,2-THIAZINE-1,1-DIOXIDES | POLAROID CORPORATION (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4359574-A | Thiazine-1,1-dioxide and isothiazole-1,1-dioxide derivatives | POLAROID CORPORATION (US) | 1982-11-16 | — | — | US | disclosed |
| US-4259498-A | Process for preparing benzisothiazole-1,1-dioxide and naphtho-1,2-thiazine-1,1-dioxide compounds | POLAROID CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |
| US-4204061-A | Sulfam(na)phthaleins | POLAROID CORPORATION (US) | 1980-05-20 | — | — | US | disclosed |
| US-4191689-A | Benzisothiazole-1,1-dioxide and naphtho-1,2-thiazine-1,1-dioxide compounds | POLAROID CORPORATION (US) | 1980-03-04 | — | — | US | disclosed |
| EP-0001290-A1 | Substituted 2,3-dihydrobenz-(d)-isothiazole-1,1-dioxides and 2,3-dihydronaphtho-(1,8-de)-1,2-thiazine-1,1-dioxides | POLAROID CORPORATION (US) | 1979-04-04 | — | — | EP | disclosed |